CHRONIC OBSTRUCTIVE PULMONARY DISEASE Decreased expression of interleukin 13 in human lung emphysema
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چکیده
Background: The overexpression of interferon (IFN)c or interleukin (IL)-13 in the adult murine lung induces the development of changes that mirror human lung emphysema. Methods: IL-13 and IFNc expression was determined in lung samples from five groups of patients: severe emphysema without a1-antitrypsin deficiency (SE+, n = 10); severe emphysema with a1-antitrypsin deficiency (SE2, n = 5); mild localised emphysema (ME, n = 8); non-emphysema smokers (NE-S, n = 9), and non-emphysema non-smokers (NE-NS, n = 11). Lung IL-13 and IFNc mRNA were analysed by RTPCR. Lung concentrations of IL-13 protein were assessed by ELISA. Results: The expression of IFNc mRNA was similar in patients with or without emphysema. IL-13 mRNA was markedly decreased in the SE+ group compared with the SE2 (p = 0.04), ME (p = 0.02), and nonemphysema groups (p = 0.01). IL-13 mRNA correlated with forced expiratory volume in 1 second (r=0.5, p = 0.04) and arterial oxygen tension (r=0.45, p = 0.03) in emphysema patients. In contrast to the nonemphysematous lung, IL-13 protein was below the detection limit of the assay in most emphysematous lung homogenates. Conclusion: The lung IL-13 content is reduced in patients with severe emphysema without a1-antitrypsin deficiency.
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